Refactor to make CellSample class more self-contained
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@@ -1,10 +1,37 @@
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import java.util.ArrayList;
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import java.util.Collections;
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import java.util.List;
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import java.util.stream.IntStream;
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public class CellSample {
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private List<Integer[]> cells;
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private Integer cdr1Freq;
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public CellSample(Integer numDistinctCells, Integer cdr1Freq){
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this.cdr1Freq = cdr1Freq;
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List<Integer> numbersCDR3 = new ArrayList<>();
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List<Integer> numbersCDR1 = new ArrayList<>();
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Integer numDistCDR3s = 2 * numDistinctCells + 1;
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IntStream.range(1, numDistCDR3s + 1).forEach(i -> numbersCDR3.add(i));
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IntStream.range(numDistCDR3s + 1, numDistCDR3s + 1 + (numDistCDR3s / cdr1Freq) + 1).forEach(i -> numbersCDR1.add(i));
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Collections.shuffle(numbersCDR3);
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Collections.shuffle(numbersCDR1);
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//Each cell represented by 4 values
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//two CDR3s, and two CDR1s. First two values are CDR3s (alpha, beta), second two are CDR1s (alpha, beta)
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List<Integer[]> distinctCells = new ArrayList<>();
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for(int i = 0; i < numbersCDR3.size() - 1; i = i + 2){
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Integer tmpCDR3a = numbersCDR3.get(i);
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Integer tmpCDR3b = numbersCDR3.get(i+1);
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Integer tmpCDR1a = numbersCDR1.get(i % numbersCDR1.size());
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Integer tmpCDR1b = numbersCDR1.get((i+1) % numbersCDR1.size());
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Integer[] tmp = {tmpCDR3a, tmpCDR3b, tmpCDR1a, tmpCDR1b};
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distinctCells.add(tmp);
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}
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this.cells = distinctCells;
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}
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public CellSample(List<Integer[]> cells, Integer cdr1Freq){
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this.cells = cells;
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this.cdr1Freq = cdr1Freq;
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@@ -288,7 +288,7 @@ public class CommandLineInterface {
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//for calling from command line
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public static void makeCells(String filename, Integer numCells, Integer cdr1Freq){
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CellSample sample = Simulator.generateCellSample(numCells, cdr1Freq);
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CellSample sample = new CellSample(numCells, cdr1Freq);
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CellFileWriter writer = new CellFileWriter(filename, sample);
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writer.writeCellsToFile();
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}
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@@ -74,7 +74,7 @@ public class InteractiveInterface {
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System.out.println(ex);
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sc.next();
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}
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CellSample sample = Simulator.generateCellSample(numCells, cdr1Freq);
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CellSample sample = new CellSample(numCells, cdr1Freq);
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assert filename != null;
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System.out.println("Writing cells to file");
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CellFileWriter writer = new CellFileWriter(filename, sample);
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@@ -23,30 +23,6 @@ public class Simulator implements GraphModificationFunctions {
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private static final int cdr1AlphaIndex = 2;
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private static final int cdr1BetaIndex = 3;
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public static CellSample generateCellSample(Integer numDistinctCells, Integer cdr1Freq) {
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//In real T cells, CDR1s have about one third the diversity of CDR3s
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List<Integer> numbersCDR3 = new ArrayList<>();
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List<Integer> numbersCDR1 = new ArrayList<>();
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Integer numDistCDR3s = 2 * numDistinctCells + 1;
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IntStream.range(1, numDistCDR3s + 1).forEach(i -> numbersCDR3.add(i));
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IntStream.range(numDistCDR3s + 1, numDistCDR3s + 1 + (numDistCDR3s / cdr1Freq) + 1).forEach(i -> numbersCDR1.add(i));
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Collections.shuffle(numbersCDR3);
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Collections.shuffle(numbersCDR1);
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//Each cell represented by 4 values
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//two CDR3s, and two CDR1s. First two values are CDR3s (alpha, beta), second two are CDR1s (alpha, beta)
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List<Integer[]> distinctCells = new ArrayList<>();
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for(int i = 0; i < numbersCDR3.size() - 1; i = i + 2){
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Integer tmpCDR3a = numbersCDR3.get(i);
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Integer tmpCDR3b = numbersCDR3.get(i+1);
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Integer tmpCDR1a = numbersCDR1.get(i % numbersCDR1.size());
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Integer tmpCDR1b = numbersCDR1.get((i+1) % numbersCDR1.size());
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Integer[] tmp = {tmpCDR3a, tmpCDR3b, tmpCDR1a, tmpCDR1b};
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distinctCells.add(tmp);
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}
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return new CellSample(distinctCells, cdr1Freq);
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}
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//Make the graph needed for matching CDR3s
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public static GraphWithMapData makeGraph(List<Integer[]> distinctCells, Plate samplePlate, boolean verbose) {
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Instant start = Instant.now();
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