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7f18311054
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@@ -12,7 +12,7 @@ Unlike pairSEQ, which calculates p-values for every TCR alpha/beta overlap and c
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against a null distribution, BiGpairSEQ does not do any statistical calculations
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directly.
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BiGpairSEQ creates a [weightd bipartite graph](https://en.wikipedia.org/wiki/Bipartite_graph) representing the sample plate.
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BiGpairSEQ creates a [weighted bipartite graph](https://en.wikipedia.org/wiki/Bipartite_graph) representing the sample plate.
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The distinct TCRA and TCRB sequences form the two sets of vertices. Every TCRA/TCRB pair that share a well
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are connected by an edge, with the edge weight set to the number of wells in which both sequences appear.
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(Sequences present in *all* wells are filtered out prior to creating the graph, as there is no signal in their occupancy pattern.)
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@@ -254,7 +254,7 @@ slightly less time than the simulation itself. Real elapsed time from start to f
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## TODO
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* ~~Try invoking GC at end of workloads to reduce paging to disk~~ DONE
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* Hold graph data in memory until another graph is read-in? ~~ABANDONED~~ ~~UNABANDONED~~ DONE
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* ~~Hold graph data in memory until another graph is read-in? ABANDONED UNABANDONED~~ DONE
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* ~~*No, this won't work, because BiGpairSEQ simulations alter the underlying graph based on filtering constraints. Changes would cascade with multiple experiments.*~~
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* Might have figured out a way to do it, by taking edges out and then putting them back into the graph. This may actually be possible.
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* It is possible, though the modifications to the graph incur their own performance penalties. Need testing to see which option is best.
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